This research aimed to reveal that extreme neurological motor deficits within the context of late tick-borne illness with combined microorganism involvement are eligible for long-term mixed antibiotic/antiparasitic remedies. The inclusion standards had been: 1. neurological limb paralysis with a incapacity rating >4 in line with the EDSS Kurtzke incapacity scale; 2. serological exams pointing to an involvement of the principle tick-borne microorganisms Borrelia burgdorferi s.l., Babesia, Anaplasma, and Bartonella; 3. a normal illness for greater than 6 months with fatigue, ache and subjective cognitive deficit. The sufferers had been administered long-term remedies with repeated cycles (a minimum of three) of 35-day IV ceftriaxone and repeated oral regimens of azithromycin–doxycycline and azithromycin–doxycycline–rifampicin. For Babesia, repeated programs of atovaquone–azithromycin had been administered. Ten sufferers had intractable or extreme motor deficits earlier than remedy within the context of Borrelia (two instances) Borrelia–Babesia (4 instances), Borrelia–Babesia–Anaplasma (two instances), Borrelia–Babesia–Anaplasma–Bartonella (one case) and Babesia–Anaplasma (one case). For a number of months, 5 had been in wheelchairs, and 4 had been strolling with sticks. Seven sufferers out of 10 (70%) confirmed full remission after a imply energetic remedy period of 20.1 + 6.6 months, with a imply variety of 4 ceftriaxone cycles. Three sufferers confirmed an preliminary remission however suffered secondary antibiotic/antiparasitic-resistant motor recurrences. Among the many 9 sufferers with Borrelia serologic positivity, remedies obtained full remission in seven instances (77%). The findings of this ten-case collection recommend the usefulness of long-term antibiotic/antiparasitic remedies in sufferers with extreme late tick-borne neurological deficits with extremely important parts of tick-borne involvement.