This research intended to show that serious neurological electric motor shortages in the context of late tick-borne condition with combined bacterium participation are qualified for long-lasting consolidated antibiotic/antiparasitic therapies. The incorporation standards were: 1. neurological arm or leg paralysis with a special needs rating >> 4 according to the EDSS Kurtzke handicap range; 2. serological examinations indicating a participation of the major tick-borne bacteria Borrelia burgdorferi s.l., Babesia, Anaplasma, as well as Bartonella; 3. a basic condition for greater than 6 months with exhaustion, discomfort as well as subjective cognitive deficiency. The people were provided long-lasting therapies with duplicated cycles (a minimum of 3) of 35-day IV ceftriaxone as well as duplicated dental programs of azithromycin– doxycycline as well as azithromycin– doxycycline– rifampicin. For Babesia, duplicated training courses of atovaquone– azithromycin were provided. 10 people had unbending or serious electric motor shortages prior to therapy in the context of Borrelia (2 situations) Borrelia– Babesia (4 situations), Borrelia– Babesia– Anaplasma (2 situations), Borrelia– Babesia– Anaplasma– Bartonella (one situation) as well as Babesia– Anaplasma (one situation). For numerous months, 5 had actually remained in mobility devices, as well as 4 had actually been strolling with sticks. 7 people out of 10 (70%) revealed total remission after a mean energetic therapy period of 20.1 + 6.6 months, with a mean variety of 4 ceftriaxone cycles. 3 people revealed a first remission yet endured additional antibiotic/antiparasitic-resistant electric motor reoccurrences. Amongst the 9 people with Borrelia serologic positivity, therapies got total remission in 7 situations (77%). The searchings for of this ten-case collection recommend the efficiency of long-lasting antibiotic/antiparasitic therapies in people with serious late tick-borne neurological shortages with extremely considerable components of tick-borne participation.