Anaplasma phagocytophilum an infection triggers encephalitis

Anaplasma phagocytophilum an infection triggers encephalitis

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Anaplasmosis hardly ever causes neurologic problems. However the authors of a brand new research, describe a affected person who developed encephalitis attributable to an an infection with Anaplasma phagocytophilum. That is believed to be the primary case reported within the literature of Anaplasma encephalitis.


Anaplasmosis is a tick-borne illness brought on by the bacterium Anaplasma phagocytophilum. Signs usually begin 1 to 2 weeks after a tick chew. And whereas some sufferers could also be asymptomatic, others can expertise life-threatening problems, together with encephalitis.

In actual fact, the mortality charge is increased in sufferers who don’t instantly obtain doxycycline remedy, who’re immunocompromised or have grow to be contaminated by way of a blood transfusion.

Of their article, Anaplasma phagocytophilum Encephalitis: A Case Report and Literature Review of Neurologic Manifestations of Anaplasmosis,” Cosiquien and colleagues describe a 62-year-old affected person who was admitted to the emergency division attributable to an acute onset of confusion.¹

The person was “confused and unable to keep up significant dialog,” the creator’s state. He had a light headache and a slight fever however no different signs.

The affected person had acute onset of confusion, a light headache and a slight fever however no different signs.

He was an avid gardener and reportedly had a tick chew 4 weeks earlier than his signs started.

“Given the signs of headache, confusion, and fever, encephalitis was suspected, and a lumbar puncture (LP) was carried out,” the creator’s state.

The person was handled empirically with acyclovir, ceftriaxone, and vancomycin. However regardless of remedy, his fever and confusion worsened over the subsequent 24 hours.

Subsequent PCR testing was optimistic for anaplasmosis and the affected person started remedy with IV doxycycline. He made a completely restoration.

 “Inside 24 hours of doxycycline initiation, his signs improved.”

Neurologic manifestations of anaplasmosis are much less widespread than in different tick-borne illnesses, corresponding to ehrlichiosis, Lyme disease, and Powassan virus an infection, in keeping with the authors.

“… our affected person responded promptly to intravenous doxycycline which additional confirms that this certainly was encephalitis attributable to Anaplasma phagocytophilum,” the creator’s state.

“As instances of anaplasmosis have gotten extra frequent, it has grow to be obvious that some sufferers, such because the one we report, current with predominantly neurological manifestations.”

The authors level out that though there was scientific and laboratory proof of encephalitis, the affected person’s MRI was regular.

They counsel, “In tick-endemic areas, clinicians ought to preserve [an infection with anaplasma phagocytophilum] in thoughts in sufferers who current with encephalitis.”


  1. Cosiquien RJS, Stojiljkovic N, Nordstrom CW, Amadi E, Lutwick L, Dumic I. Anaplasma phagocytophilum Encephalitis: A Case Report and Literature Evaluation of Neurologic Manifestations of Anaplasmosis. Infectious Illness Experiences. 2023; 15(4):354-359.

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