Autism (ASD) signs enhance following therapy for Lyme disease

Autism (ASD) signs enhance following therapy for Lyme disease

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Of their case report, investigators describe a toddler with autism spectrum dysfunction (ASD), whose cognitive and neuropsychiatric signs resolved utterly or improved considerably after he was handled with antibiotics for Lyme disease and Bartonella.


“Case report: Substantial improvement of autism spectrum disorder in a child with learning disabilities in conjunction with treatment for poly-microbial vector borne infections,” by Drs. Offutt and Breitschwerdt describes the case of an adolescent identified with autism spectrum dysfunction, who had cognitive and neuropsychiatric signs which improved following therapy for Lyme disease and Bartonella.¹

The 14-year-old boy had been sick for years with neurologic and psychiatric points and had visited a number of physicians in search of a proof to the fluctuating nature of those signs.

His extreme signs included: ADD/ADHD, tics (neck roll), nervousness, child discuss, immaturity, dysgraphia, oppositional habits, low studying comp, stammering, despair, anger, choosy consuming and mattress wetting.

On a number of events, the younger man had behavioral outbursts, which led to his working away from residence. He had acquired a number of diagnoses, together with:

  • Cerebellar hypoplasia (in utero)
  • ADHD (onset at age 5)
  • PANS – pediatric acute-onset neuropsychiatric syndrome (onset throughout elementary faculty; formally identified at age 10)
  • Autism (onset throughout elementary faculty; identified at age 14)
  • Autoimmune encephalopathy (identified at age 14)

At age 10, the Cunningham Panel™ of tests revealed the presence of anti-neuronal antibodies with a borderline anti-Tubulin assay. At age 14, he was identified with autoimmune encephalitis and started therapy with intravenous immunoglobulin (IVIG), which briefly improved his signs.

“This case report gives additional assist to the rising physique of literature indicating that infectious triggers could contribute to neuropsychiatric problems…”

Additional testing revealed the younger man had been uncovered to a number of tick-borne infections with serologic proof of Bartonella and Lyme disease.

The affected person was prescribed numerous therapies for Lyme disease and Bartonella.  The record included amantadine, doxycycline, minocycline, amoxicillin, amoxicillin/clavulanate, clindamycin, IV ozone, gluten-free food regimen and a dairy-free food regimen.

“Following the introduction of a drug, most therapeutics, significantly antibiotics, had been rapidly discontinued on account of insupportable negative effects and flaring of behavioral signs,” wrote the authors.

“A transition to a brand new therapeutic routine was carried out, progressively administering particular person or combos of a number of completely different antimicrobial brokers, together with disulfiram, rifampin, minocycline, rifabutin, clarithromycin, and methylene blue (18–20).”

Different therapies included probiotics, antioxidants, and anti-inflammatories.

Antibiotic therapies resulted in “substantial enchancment” in cognitive and neurobehavioral signs, corresponding to oppositional, defiant, anti-social, disordered temper, immaturity, tics.

The affected person responded positively with a discount or decision of signs at the side of antibiotic remedy.  He had a dramatic enchancment in cognitive features and was accepted right into a 4-year faculty.

Lyme disease and Bartonella therapy led to a number of symptom enhancements:

“Oppositional habits and anger improved virtually instantly after the initiation of disulfiram and these signs remained clear all through the therapy interval,” the authors wrote, however famous “squealing, grunting, grimacing, and stammering worsened when disulfiram was launched.”

The boy’s “tutorial testing transitioned from the particular schooling degree to tenth grade degree, as he not required the particular lodging that had been supplied at his faculty.”

He transitioned to an everyday classroom, was capable of keep enough tutorial efficiency, improved his social expertise, take a university entrance examination, and was accepted in a 4-year college.

Sadly, he was unable to discontinue the antibiotics and not using a flareup.

“His response to this therapeutic strategy included enchancment or elimination of a considerable variety of neuropsychiatric signs and important enchancment in his tutorial standing…”

The authors granted that their affected person had a well-defined embryonic abnormality identified in utero. But, “A choice was made to deal with with antimicrobial brokers focusing on a possible infectious etiology, with secondary auto-antibody formation.”

They inspired additional analysis to outline the extent to which occult infections can contribute to neuropsychiatric sickness and signs related to autism spectrum dysfunction.

Authors conclude:

  • “We suggest {that a} threat/profit evaluation in most sufferers identified with autism spectrum dysfunction would warrant analysis and therapy for potential continual infectious triggers.”
  • “This case report gives additional assist to the rising physique of literature indicating that infectious triggers could contribute to neuropsychiatric problems, together with these in kids who phenotypically current as academically challenged, or meet the factors for autism spectrum dysfunction.”


  1. Offutt A, Breitschwerdt EB. Case report: Substantial enchancment of autism spectrum dysfunction in a toddler with studying disabilities at the side of therapy for poly-microbial vector borne infections. Entrance Psychiatry. 2023;14:1205545. doi:10.3389/fpsyt.2023.1205545

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