Extreme anaplasmosis results in multi-organ issues

Extreme anaplasmosis results in multi-organ issues

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Anaplasmosis can current with a variety of signs, making it difficult to diagnose. The commonest signs embrace fever, headache, muscle aches, fatigue, and chills. Nonetheless, in extreme circumstances, anaplasmosis can have an effect on a number of organ methods, inflicting respiratory failure, kidney failure, and bleeding issues. In uncommon circumstances, it may be deadly.


Of their case report “Severe Anaplasmosis With Multiorgan Involvement in a Rheumatoid Arthritis Patient,” Aydin et al. describe a 66-year-old girl, residing in Connecticut, who was admitted to the emergency division with confusion and lethargy.

The affected person was disoriented and had been experiencing fever, chills, generalized weak point, and poor urge for food over the previous 2 days.

She had a medical historical past of rheumatoid arthritis and hypothyroidism.

The affected person loved gardening and reportedly had a number of tick bites in her left armpit 3 days earlier than she introduced to the hospital. However she didn’t have any noticeable rashes.

“Involved about her worsening psychological standing, the husband promptly contacted emergency providers,” states Aydin.

“Immediate prognosis and therapy are important to forestall issues that may embrace respiratory failure, kidney failure, bleeding issues and in uncommon circumstances, dying.”

Laboratory testing revealed pancytopenia, hyponatremia, elevated liver enzymes with gentle hyperbilirubinemia, and lactic acidosis.

PCR testing supported the medical prognosis of extreme anaplasmosis.

Though the girl was handled promptly with doxycycline, her conditioned worsened and she or he developed acute hypoxic respiratory failure secondary to acute respiratory misery syndrome.

“… because of the illness’s development, the affected person developed [acute respiratory distress syndrome] necessitating the usage of HFNC remedy to keep up sufficient oxygenation.”

Because the authors level out, the affected person was on immunosuppressant medicines for her arthritis, which seemingly contributed to the worsening of her signs and to the broad vary of medical manifestations that affected a number of organ methods.

“The well timed initiation of applicable therapy, particularly the administration of doxycycline, proved to be essential in stopping additional issues and selling the affected person’s restoration,” the authors state.

The authors recommend, this case “highlights the necessity for healthcare suppliers to keep up a excessive index of suspicion, acknowledge the illness early on, and promptly provoke applicable therapy. By doing so, extreme issues could be prevented, and affected person outcomes could be considerably improved.”


  1. Aydin Y, Vemuri B, Ahmed SM, Elgamal M, Bilgin S. Extreme Anaplasmosis With Multiorgan Involvement in a Rheumatoid Arthritis Affected person. Cureus. 2023 Jul 7;15(7):e41536. doi: 10.7759/cureus.41536. PMID: 37554613; PMCID: PMC10404564.

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