How efficient is mixture antibiotic therapy for tick-borne infections?

How efficient is mixture antibiotic therapy for tick-borne infections?

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On this examine, performed in Dublin, Eire, investigators examined the efficacy of mixture antibiotic therapy on numerous varieties of tick-borne infections.


Of their article “A Longitudinal Study of a Large Clinical Cohort of Patients with Lyme Disease and Tick-Borne Co-Infections Treated with Combination Antibiotics” Xi and colleagues checked out 140 people who examined optimistic for tick-borne infections (TBI) with 33% of these sufferers contaminated with a number of TBIs.¹

The authors discovered that out of the 140 members:

  • 93 (66.43%) had optimistic antibody responses to 1 tick-borne an infection
  • 83 (59.29%) had been optimistic for Borrelia
  • 7 (5.00%) had been optimistic for Rickettsia
  • 1 (0.71%) every for both Babesia, Bartonella, or Ehrlichia

The remaining 47 (33.57%) sufferers had been contaminated with a number of tick-borne infections, together with Borrelia, Babesia, Bartonella, Ehrlichia and Rickettsia.

The vast majority of sufferers had been handled with a triple antibiotic mixture routine.

Many of the members obtained 500 mg cefuroxime, 300 mg rifampicin, and 300 mg lymecycline. Therapy length ranged between 12 and 40 weeks.

Within the first follow-up go to with 118 sufferers, 59% reported having ache and 41% had neurological signs. In the meantime, there was continued enchancment in affected person signs on the second follow-up go to. Out of 101 sufferers, 41% reported having ache and 30% had neurological signs.

“There have been statistically important reductions within the incidence of ache and neurological signs between follow-ups,” the authors wrote.

“Thus, our examine demonstrates that mixture antibiotics successfully relieve TBI signs with good affected person tolerance.”

Based on the survey, 52% of sufferers recalled having a tick chunk, whereas 46% didn’t exhibit a bull’s-eye rash.

The sufferers exhibited important enhancements of their well being standing throughout the first and second follow-up visits.

“The three commonest signs reported by the sufferers had been ache, fatigue, and neurological signs, similar to a tingling sensation within the limbs and reminiscence defects,” the authors wrote.

On the second follow-up go to, “The variety of sufferers affected by ache, neurological signs, and fatigue decreased by 41.43%, 37.50%, and 17.54%, respectively,” in line with the authors.

The advance in ache and neurological signs was important however fatigue continued to be problematic for sufferers.

Authors Takeaways:

  • “Our examine established that the majority sufferers on this cohort had been contaminated with the Borrelia burgdorferi species, and a few third had co-infections with different tick-borne pathogens.”
  • “Roughly half of the sufferers recalled receiving a tick chunk and creating a bull’s-eye rash.”
  • “Ache, fatigue, and neurological signs had been among the many commonest persistent signs.”


  1. Xi D, Thoma A, Rajput-Ray M, Madigan A, Avramovic G, Garg Ok, Gilbert L, Lambert JS. A Longitudinal Research of a Massive Scientific Cohort of Sufferers with Lyme Illness and Tick-Borne Co-Infections Handled with Mixture Antibiotics. Microorganisms. 2023; 11(9):2152.

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