Once I first began treating Lyme disease again within the early Nineties, our scientific understanding was that the micro organism, Borrelia burgdorferi, had a cell wall kind which was conscious of cell wall medicine like penicillins and cephalosporins; an intracellular kind, conscious of intracellular antibiotics (tetracyclines, macrolides, quinolones); and cystic kinds, in any other case referred to as cell wall poor kinds/L-forms/S-forms/spherical our bodies. I printed in a scientific summary, through the 12th Worldwide Convention on Lyme Illness and Different Spirochetal and Tickborne Problems, April 1999, the primary article on using Flagyl/metronidazole for the remedy of continual Lyme disease, based mostly on work that I did with Dr Martin Atkinson Barr.
Metronidazole Remedy within the Remedy of Power Lyme Illness. Horowitz, R.I., M.D. twelfth Worldwide Convention on Lyme Illness and Different Spirochetal and Tick-Borne Problems, April 9-10, 1999. New York, New York.
We didn’t know on the time that metronidazole hit the cystic types of Borrelia, and Dr. Brorson confirmed that roughly six months later in a scientific publication. So for years, I used to be combining a cell wall drug (Ceftin, Omnicef, Bicillin injections, IV Rocephin), discovering that longer appearing antibiotics like Bicillin have been efficient when blended with Plaquenil (hydroxychloroquine) and/or Flagyl for the spherical physique types of Borrelia (Plaquenil additionally was additionally proven to be efficient in hitting the cystic types of Borrelia, in keeping with Dr. Brorson), together with an intracellular drug like Zithromax.
Bicillin Remedy and Lyme Illness: A Retrospective Research of the Security and Efficacy of Excessive Dose Intramuscular Bicillin within the Remedy of Power resistant Lyme Illness. Horowitz, R.I., M.D. twelfth Worldwide Convention on Lyme Illness and Different Spirochetal and Tick-Borne Problems, April 9-10, 1999. New York, New York
This was efficient in serving to sufferers, however many occasions, sufferers relapsed shortly after stopping remedy because of persistent an infection and required natural therapies to cut back their signs and/or assist a few of them keep in remission.
Power Persistent Lyme Borreliosis: PCR Proof of Power An infection Regardless of Prolonged Antibiotic Remedy- A Retrospective Overview Horowitz R.I., M.D. Summary, thirteenth Annual Worldwide Scientific Convention on Lyme Illness and different Tick-Borne Problems. Hartford, Connecticut, March 25-26,2000.
Then through the years, one after the other I discovered overlapping sources of irritation with downstream results that have been preserving my sufferers in poor health. First it was co-infections, particularly Babesia. Joe Burrascano inspired me to publish my findings (thanks, Joe!). We discovered Babesia microti in each ticks and in my sufferers. Considered one of my sufferers who was in a wheelchair for 5 years unable to stroll, started to ambulate for the primary time after taking 10 days of Mepron and Zithromax. The abstracts are listed under.
Babesiosis in Upstate New York: PCR and RNA Proof of Co-An infection with Babesia Microti Amongst Ixodidae Ticks in Dutchess County, NY. Horowitz, R.I., M.D. twelfth Worldwide Convention on Lyme Illness and Different Spirochetal and Tick-Borne Problems, April 9-10, 1999. New York, New York
Atovaquone and Azithromycin Remedy: A New Remedy Protocol for Babesiosis in Co-Contaminated Lyme Sufferers. Horowitz, R.I., M.D. eleventh Worldwide Convention on Lyme Illness and Different Spirochetal and Tick-Borne Problems, April 25-26, 1998. New York, New York.
Power Lyme Illness: A Symptom Advanced of A number of Co-Infections: New Diagnostic & Remedy Protocols. Horowitz, R.I., M.D. twelfth Worldwide Convention on Lyme Illness and Different Spirochetal and Tick-Borne Problems, April 9-10, 1999. New York, New York.
Lyme Illness and Babesiosis: New Therapeutic Choices for Power Persistent Illness. Horowitz R.I., M.D.. Summary, thirteenth Annual Worldwide Scientific Convention on Lyme Illness and different Tick-Borne Problems. Hartford, Connecticut, March 25-26,2000.
Mefloquinine and Artemesia: A Potential Trial of Mixture Remedy in Power Babesiosis Horowitz R.I., M.D. Summary, thirteenth Annual Worldwide Scientific Convention on Lyme Illness and different Tick-Borne Problems. Hartford, Connecticut, March 25-26,2000.
Excessive Dose Trimethoprim-Sulfamethoxazole Remedy: A Helpful Adjunct to Mixture Remedy within the Remedy of Resistant Babesiosis. Horowitz, R.I., M.D. twelfth Worldwide Convention on Lyme Illness and Different Spirochetal and Tick-Borne Dis-orders, April 9-10, 1999. New York, New York
Then after discovering Babesia was enjoying an vital position in preserving sufferers in poor health, we discovered that Bartonella was doing the identical. A affected person who couldn’t communicate for years, who had been to a significant college hospital and advised that she had an ‘atypical migraine’ started speaking for the primary time in a number of years after giving her tetracyclines and a quinolone after we discovered she had Bartonella! This was 21 years in the past! We’re nonetheless discovering Bartonella is enjoying a significant position in preserving our sufferers in poor health, with new species being found on a regular basis. The abstracts under talk about the issues with testing and remedy for Bartonella, again in 2003:
Bartonella Henselae: Limitations of Serological Testing: Analysis of Elisa and Polymerase Chain Response Testing In a Cohort of Lyme Illness Sufferers and Implications for Remedy. Horowitz R.I., M.D. et.al. Summary, sixteenth Worldwide Scientific Convention on Lyme Illness & Different Tick-Borne Problems. Hartford, Connecticut, June 2003.
Borrelia Burgdorferi & Bartonella Henselae: A Research Evaluating Tetracyclines In Mixture with Quinolones in Co-Contaminated Sufferers. Horowitz R.I., M.D. et.al. Summary, sixteenth Worldwide Scientific Convention on Lyme Illness & Different Tick-Borne Problems. Hartford, Connecticut, June 2003.
And if it wasn’t Babesia and Bartonella, we then discovered atypical Mycoplasma species contributing to ongoing irritation:
Mycoplasma Infections in Power Lyme Illness: A Retrospective Evaluation of Co-An infection and Persistence Demonstrated by PCR Evaluation Regardless of Lengthy Time period Antibiotic Remedy. Horowitz R.I., M.D. et.al. Summary, 16th Worldwide Scientific Convention on Lyme Illness & Different Tick-Borne Problems. Hartford, Connecticut, June 2003.
Power Lyme Illness: A Symptom Advanced of A number of Co-Infections: New Diagnostic & Remedy Protocols. Horowitz, R.I., M.D. twelfth Worldwide Convention on Lyme Illness and Different Spirochetal and Tick-Borne Problems, April 9-10, 1999. New York, New York.
So 12 months after 12 months, we saved discovering new components that have been contributing to continual sickness, whether or not it was heavy metallic toxicity or mildew…
A Potential Research of Heavy Steel Publicity Amongst Lyme Illness Sufferers with Power Persistent Symptomatology: Implications for Remedy. Horowitz R.I., M.D. et.al. Summary, sixteenth Worldwide Scientific Convention on Lyme Illness & Different Tick-Borne Problems. Hartford, Connecticut, June 2003.
Or a rise within the acidic byproducts from infections contributing to Herxheimer reactions:
Results of Shifting the Acid-Base Steadiness Amongst Lyme Sufferers throughout Jarish Herxheimer Flares: A Small Potential Research. Horowitz R.I., M.D. et.al. Summary, sixteenth Worldwide Scientific Convention on Lyme Illness & Different Tick-Borne Problems. Hartford, Connecticut, June 2003.
Or discovering that we wanted to guard our pregnant sufferers due to maternal-fetal transmission and continual persistence of Borrelia:
Lyme Illness and Being pregnant: Implications of Power An infection, PCR Testing and Prenatal Remedy. Horowitz R.I. et.al. Summary, sixteenth Worldwide Scientific Convention on Lyme Illness & Different Tick-Borne Problems. Hartford, Connecticut, June 2003.
That’s how I developed the 16-point MSIDS mannequin (A number of Systemic Infectious Illness Syndrome). One after the other, I saved discovering overlapping components that contributed to my affected person’s continual sickness, a few of them inflicting irritation straight (infections, toxins, imbalances with the microbiome with or with out mast cell activation, vitamin and mineral deficiencies, sleep issues) or downstream results of the irritation (mitochondrial dysfunction, POTS/dysautonomia, autoimmunity, ache syndromes, bodily deconditioning, hormonal dysregulation, liver dysfunction, and/or neuropsychiatric sickness).
I printed the outcomes of my findings on the MSIDS mannequin in Healthcare in 2018, in addition to in my NY Instances Bestseller, ‘Why Can’t I Get Higher? Fixing the Thriller of Lyme and Power Illness’ and Nationwide Bestseller ‘How Can I Get Higher? An Motion Plan for Treating Power LD and Resistant Sickness’.
Horowitz, R.I.; Freeman, P.R. Precision Drugs: The Function of the MSIDS Mannequin in Defining, Diagnosing, and Treating Power Lyme Illness/Put up Remedy Lyme Illness Syndrome and Different Power Sickness: Half 2. Healthcare 2018, 6, 129. https://www.ncbi.nlm.nih.gov/pubmed/30400667
Why Can’t I Get Higher? Richard Horowitz, M.D. HC ISBN-13: 978-1-250-01940-0 ISBN-10: 1-250-01940-0 6 1/8 9 ¼ ● 526 pages EISBN-13: 978-1-250-03848-7
How Can I Get Higher? Richard Horowitz, M.D. HC ISBN 978-1-250-07054-8 (hardcover) ISBN 978-1-250-11144-9 (e-book)
What saddens me wanting again in any respect of my work and publications, is that I used to be outlining the components preserving my 13,000 + sufferers in poor health over 20 years in the past, and we’re nonetheless debating whether or not Lyme is a continual persistent an infection; the position of co-infections like Babesia and Bartonella in continual sickness; whether or not Borrelia might be transmitted from mom to youngster, or whether or not practical drugs approaches are useful, and must be the brand new normal of care. I do know that advances within the discipline of medication might be sluggish, however contemplating the numerous improve within the variety of affected people who’re sick and affected by continual Lyme disease and related infections, largely because of vector-borne infections rising with local weather change, when blended with blatant disregard for printed science by sure key organizations…this example has left us in a medical-political quagmire that has successfully stifled complete affected person care. Dr. Ken Liegner precisely described this example a few years in the past when he mentioned, “Within the fullness of time, the mainstream dealing with of continual Lyme disease will likely be seen as probably the most shameful episodes within the historical past of medication as a result of components of educational drugs, components of presidency and nearly all the insurance coverage trade have colluded to disclaim a illness.”
