There are solely a handful of printed circumstances describing the impression of Lyme disease on the kidneys. Of their article “Lyme disease-associated glomerulonephritis,” Mc Causland and colleagues spotlight a number of circumstances of glomerulonephritis (irritation and injury to the filtering a part of the kidneys) as a consequence of Lyme disease. [1]
Case #1
A 57-year-old lady offered to the hospital with shortness of breath. Two weeks earlier, she skilled nausea, fatigue, headache and myalgias, earlier than growing dyspnea on reasonable exertion, the authors state. She additionally reportedly had a rash on her shoulder.
She was identified with Lyme disease and initially handled with doxycycline. Involved that she might have disseminated Lyme disease, the girl was later switched to intravenous ceftriaxone.
“Findings included world hypercellularity, mesangial enlargement and subendothelial deposits according to an immune complex-mediated membranoproliferative glomerulonephritis,” the authors state.
The affected person was handled efficiently with steroids and antibiotics.
The authors recommend, “the temporal relationship, multisystem presentation, attribute histology and response to antibiotics and steroids are according to a B. burgdorferi induced, immune complex-mediated, glomerulopathy.”
Case #2
A 40-year-old man from Massachusetts offered to the emergency division with gross hematuria (blood within the urine). One week prior, he had been bitten by a tick and subsequently developed myalgias, sore throat, headache and fever.
“The urine sediment revealed dysmorphic crimson cells and crimson cell casts … a renal biopsy revealed focal proliferation, one mobile crescent and mesangial IgA reactivity, according to IgA nephropathy,” the authors state.
“The temporal relationship to Lyme an infection (and subsequent quiescence with therapy) raises the likelihood that the acute flare was brought on by an intense activation of the immune response.”
The affected person started therapy with excessive dose oral steroids.
Throughout this era, he developed a macular rash in his armpit.
Testing for Lyme disease was constructive and the person was prescribed oral doxycycline.
This case “raises the likelihood that Lyme an infection can result in activation of a beforehand quiescent glomerular situation,” the authors state.
Authors Conclude:
- “Lyme-associated glomerular illness needs to be thought of in sufferers from endemic areas presenting with nephritis.”
References:
- Finnian R. Mc Causland, Sophie Niedermaier, Vanesa Bijol, Helmut G. Rennke, Mary E. Choi, John P. Forman, Lyme disease-associated glomerulonephritis, Nephrology Dialysis Transplantation, Quantity 26, Situation 9, September 2011, Pages 3054–3056, https://doi.org/10.1093/ndt/gfr335
