Post-mortem reveals a number of Borrelia species in mind of man with power Lyme disease

Post-mortem reveals a number of Borrelia species in mind of man with power Lyme disease

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A number of autopsy research have demonstrated the presence of Borrelia spirochetes within the mind and central nervous system of sufferers with a historical past of Lyme disease. On this case report, investigators add to the rising proof that Borrelia spirochete can reside in mind tissue even after extended antibiotic remedy.

Of their article, “Concurrent Infection of the Human Brain with Multiple Borrelia Species,” Golovchenko and colleagues describe the case involving a autopsy mind post-mortem on a person who suffered for greater than 10 years with neurologic and psychiatric signs because of Lyme disease.

The affected person underwent repeated testing with “borderline positivity for Borrelia an infection, adopted by the prescription of a number of antibiotics, which offered no medical enhancements, adopted by hospitalization at psychiatric clinics,” the authors state.

CASE REPORT

The 28-year-old affected person visited his doctor in 2004 after growing an erythema migrans (EM) rash. Subsequently, he was recognized with Lyme disease and handled with antibiotics.

Nonetheless, his situation worsened and he started exhibiting neurological signs, together with “mind fog,” lowered psychomotor efficiency and difficulties with focus and processing of visible and auditory stimuli.

“Right here we report the case of a affected person who, after being contaminated by Borrelia and handled with antibiotics repeatedly, progressed towards neurologic/psychiatric signs over the following 13 years.”

In 2017, take a look at outcomes have been constructive for Borrelia with each IgG and IgM anti-Borrelia antibodies in serum. A number of months later, he was admitted to the Psychiatric Division of the College Hospital Olomouc within the Czech Republic.

On February 2018, testing revealed borderline positivity for Borrelia-specific IgM and powerful positivity for IgG.

The IgM immunoblot was constructive for the presence of OspC from B. afzelii, B. garinii, and B. burgdorferi s.s., and the IgG immunoblot was borderline constructive for VlsE from B. afzelii, B. garinii, and B. burgdorferi s.s.

The affected person was prescribed a mix of antibiotics which included: minocycline, azithromycin, and hydroxychloroquine.

Spirochetes present in mind tissue of Lyme disease affected person

Seven months later, he was hospitalized once more and recognized with schizotypal character dysfunction and somatoform dysfunction and discharged.

One yr later, the affected person dedicated suicide.

“The affected person left behind a letter expressing the pressing demand for scientists to investigate his mind for the presence of [Lyme disease] spirochetes.”

An post-mortem was carried out.

“PCR evaluation was carried out on totally different elements of the mind to find out if Borrelia may very well be detected within the mind,” the authors state.

Testing confirmed the presence of DNA in 2 spirochete species – B. burgdorferi and B. garinii.

Every Borrelia species, nonetheless, was discovered in numerous elements of the mind.

“Although each spirochete species have been concurrently current in human mind tissue, the mind areas the place the 2 species have been detected have been totally different and non-overlapping,” the authors clarify.

B. burgdorferi was detected within the temporal proper lobe, choroid plexus, occipital lobe and parietal lobe. B. garinii DNA was discovered within the basal ganglia and cerebellum.

Authors conclude:

  • “Our outcomes confirmed the presence of two species of spirochetes from the B. burgdorferi sensu lato advanced, B. garinii and B. burgdorferi s.s., in numerous areas of the human mind.”
  • “Importantly, the DNAs of the 2 spirochete species have been detected in distinct areas of the mind; in no case did we discover an infection with each in the identical mind area.”
  • “The detection of intact spirochetes in post-mortem mind specimens of people after prolonged therapies and people with a various historical past of illness manifestations, together with widely known neurocognitive issues, anxiousness, melancholy, reminiscence loss, mind atrophy, and progressive dementia, illustrates that persistent Borrelia an infection can result in a persistent dysfunction of the central nervous system (CNS) and the event of [Lyme neuroborreliosis].”

 

References:
  1. Golovchenko M, Opelka J, Vancova M, Sehadova H, Kralikova V, Dobias M, Raska M, Krupka M, Sloupenska Ok, Rudenko N. Concurrent An infection of the Human Mind with A number of Borrelia Species. Int J Mol Sci. 2023 Nov 29;24(23):16906. doi: 10.3390/ijms242316906. PMID: 38069228; PMCID: PMC10707132.



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