Research finds potential therapeutic goal to fight mitochondrial dysfunction after TBI — Concussion Alliance

Research finds potential therapeutic goal to fight mitochondrial dysfunction after TBI — Concussion Alliance

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By Josh Wu. This text was initially revealed within the 4/11/24 version of our Concussion Replace e-newsletter; please take into account subscribing.

The journal Neurochemistry Worldwide lately revealed a review that particulars the position of mitochondria in traumatic brain injury (TBI). Sustaining wholesome mitochondria, often known as mitostasis, is essential for mind well being because of the mind’s excessive power calls for and reliance on mitochondria for power manufacturing. Authors Hubbard et al. discovered that TBIs disrupt the pure steadiness of mitochondria perform within the mind, resulting in secondary results like cell injury, lack of neurotransmitters, and total cognitive decline.

Nevertheless, this new analysis into mitochondria has discovered that mitochondrial uncoupling, a course of that decouples ATP manufacturing from oxygen consumption, helps regulate the state of mitochondria in response to environmental modifications, like TBIs. Mitochondrial uncoupling could scale back the opposed physiological results of TBIs and induce the elimination of unhealthy mitochondria. Whereas the connection between mitochondria and TBIs remains to be being unraveled, mitochondrial uncoupling gives an avenue for future TBI therapies that may enhance mitochondrial well being – which is able to improve total neurological functioning. 



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